产品名称

英文名称：Hydroxyfasudil

同义词

HYDROXYFASUDIL、105628-72-6、Hydroxy-Fasudil、HA-1100、1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine、5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one、Hydroxyfasudil free base、5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one、FASUDIL IMPURITY 5、EYH4A

产品性质

CAS编号：105628-72-6

分子式：C14H17N3O3S

分子量：307.37

PubChem编号：3064778

英文别名：HYDROXYFASUDIL|105628-72-6|Hydroxy-Fasudil|HA-1100|1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine|5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one|Hydroxyfasudil free base|5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one|FASUDIL IMPURITY 5|EYH4A

规格或纯度：≥98%

英文名称：Hydroxyfasudil

生化机理：Fasudil (1-10 μM) and hydroxyfasudil (0.3-10 μM) significantly prevented endothelin-induced cardiomyocyte hypertrophy [2]. Hydroxyfasudil significantly attenuated serotonin (IC)-induced vasoconstriction of SA (-7 +/- 1% vs. 2 +/- 1%, p < 0.01). Coronary I/R significantly impaired coronary vasodilation to acetylcholine after I/R (SA, p < 0.05; and A, p < 0.01 vs. before I/R) and L-NMMA further reduced the vasodilation, whereas hydroxyfasudil completely preserved the responses.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：5mg、100mg卖完停产，不再备货

产品介绍：Hydroxyfasudil(HA1100)是Fasudil的代谢物，对ROCK1和ROCK2的IC50分别为120nM和170nM，还是血管舒张剂。Hydroxyfasudil(HA1100), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.

IUPAC Name：5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one

INCHI：InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)

InChi Key：ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

Canonical SMILES：C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O

Isomeric SMILES：C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O

PubChem CID：3064778

溶解性：25°C DMSO

产品包装