产品名称

英文名称：Deferasirox

同义词

Exjade、ICL 670、4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid、Deferasirox 100 microg/mL in Acetonitrile、Deferasorox、Deferasirox (Exjade)、Q2838752、Deferasirox Oral Granules、FT-0601564、BOFQWVMAQOTZIW-UHFFFAOYSA-N、DEFERASIROX (MART.)、DEFERASI、地拉罗司

产品性质

CAS编号：201530-41-8

分子式：C21H15N3O4

分子量：373.36

MDL号：MFCD09951804

PubChem编号：214348

别名：地拉罗司

英文别名：Exjade|ICL 670|4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid|Deferasirox 100 microg/mL in Acetonitrile|Deferasorox|Deferasirox (Exjade)|Q2838752|Deferasirox Oral Granules|FT-0601564|BOFQWVMAQOTZIW-UHFFFAOYSA-N|DEFERASIROX (MART.)|DEFERASI

规格或纯度：≥99%

英文名称：Deferasirox

生化机理：Tridentate iron chelator that is orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Deferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. The half-life of deferasirox is between 8 and 16 hours allowing once a day dosingA tridentate chelator that binds iron with high affinityDeferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. The half-life of deferasirox is between 8 and 16 hours allowing once a day dosingA tridentate chelator that binds iron with high affinity

ALogP：3.8

IUPAC Name：4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid

INCHI：InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)

InChi Key：BOFQWVMAQOTZIW-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O

Isomeric SMILES：C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O

PubChem CID：214348

溶解性：Soluble in water (<1 mg/ml at 25 °C), DMSO (75 mg/ml at 25 °C), ethanol (2 mg/ml at 25 °C), methanol, and ethyl acetate.

敏感性：对空气敏感，对热敏感

熔点：262 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH410 Very toxic to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn childH312+H332 Harmful in contact with skin or if inhaled

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319

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