产品名称

英文名称：Alvespimycin

同义词

alvespimycin、467214-20-6、17-DMAG、DMAG、Alvespimycin [INN]、KOS1022、17-dimethylaminoethylamino-17-demethoxygeldanamycin、KOS 1022、CHEBI65324、17-(dimethylaminoethylamino)-17-demethoxygeldanamycin、150270-08-9、17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDAN、NSC 707545、阿螺旋霉素

产品性质

CAS编号：467214-20-6

分子式：C32H48N4O8

分子量：616.75

PubChem编号：5288674

别名：NSC 707545|阿螺旋霉素

英文别名：alvespimycin|467214-20-6|17-DMAG|DMAG|Alvespimycin [INN]|KOS1022|17-dimethylaminoethylamino-17-demethoxygeldanamycin|KOS 1022|CHEBI65324|17-(dimethylaminoethylamino)-17-demethoxygeldanamycin|150270-08-9|17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDAN

规格或纯度：98%

英文名称：Alvespimycin

生化机理：17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG .17-DMAG is described to bind and inhibit the activity of Hsp90 (heat shock protein 90), a cellular chaperone that is over expressed in many cancers, and which participates in folding of proteins found in multiple signal transduction pathways.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：100mg卖完停产，不再备货

产品介绍：Alvespimycin (17-DMAG; KOS-1022; NSC 707545)是水溶性HSP90抑制剂，IC50为62 nM。A synthetic Geldanamycin derivative and inhibitor of Hsp90.A synthetic Geldanamycin derivative and inhibitor of Hsp90.

IUPAC Name：[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate

INCHI：InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1

InChi Key：KUFRQPKVAWMTJO-LMZWQJSESA-N

Canonical SMILES：CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC

Isomeric SMILES：C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC

关联CAS：467214-20-6

PubChem CID：5288674

MeSH Entry Terms：17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin;17-(dimethylaminoethylamino)-17-demethoxygeldanamycin;17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin;17-dimethylaminoethylamino-17-demethoxy-geldanamycin;17-DMAG;17DMAG;alvespimycin;KOS 102

溶解性：Soluble in water, ethanol (10 mg/mL), and DMSO (>25 mg/mL).

产品包装