产品名称

英文名称：Gefitinib (ZD1839)

同义词

ZD 1839、AM20090619、Gefitinib [USANINNBAN]、SY017890、CHEBI49668、nchembio866-comp14、4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline、4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-、GEFITINI、吉非替尼

产品性质

CAS编号：184475-35-2

分子式：C22H24ClFN4O3

分子量：446.9

MDL号：MFCD04307832

PubChem编号：123631

别名：吉非替尼

英文别名：ZD 1839|AM20090619|Gefitinib [USANINNBAN]|SY017890|CHEBI49668|nchembio866-comp14|4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-|GEFITINI

规格或纯度：≥99%

英文名称：Gefitinib (ZD1839)

生化机理：Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. Studies sμggest that gefitinib can enhance keratinocyte apoptosis via an EGFR-independent JNK-activation pathway. Research indicates that gefitinib can induce apoptosis in several cell lines including, HaCaT cells, KG-1, P39, and primary CD34+ myeloblasts.Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC 50 = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo . Enhances efficacy of cytotoxic agents.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Gefitinib (ZD1839)是一种EGFR抑制剂，作用于NR6wtEGFR和NR6W细胞中的Tyr1173，Tyr992，Tyr1173和Tyr992，IC50 分别为37 nM，37nM，26 nM和57 nM。An EGFR-tyrosine kinase inhibitorGefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.An EGFR-tyrosine kinase inhibitor

ALogP：4.1

IUPAC Name：N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

INCHI：InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChi Key：XGALLCVXEZPNRQ-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

Isomeric SMILES：COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

PubChem CID：123631

DrugBank Ligand：DB00317

Wikipedia：Gefitinib

ChEBI：CHEBI49668

CAS Registry No.：184475-35-2

DiscoveRx TREEspot：Gefitinib|

ChEMBL Ligand：CHEMBL939

RCSB PDB Ligand：IRE

PEP：gefitinib

Reactome Reaction：R-HSA-9665121, R-HSA-1220610

Reactome Drug：R-ALL-1169429

DrugCentral Ligand：1282

溶解性：Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).

敏感性：对热敏感

比旋光度：1.62

沸点：586.8 °C

熔点：194.0 to 198.0 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH400 Very toxic to aquatic lifeH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P330,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P332+P317,P319

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