产品名称

英文名称：Rilpivirine

同义词

4-{[4-({4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile、AC-30619、W-202888、R278474;TMC278、GTPL11387、MFCD11046372、YIBOMRUWOWDFLG-ONEGZZNKSA-N、EN300-21682062、R278474、R-278474、Rilpivirine [INN]、RILPIVIRINE [JAN]、BCP9000016、S、利吡韦林

产品性质

CAS编号：500287-72-9

分子式：C22H18N6

分子量：366.42

PubChem编号：6451164

别名：利吡韦林

英文别名：4-{[4-({4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile|AC-30619|W-202888|R278474;TMC278|GTPL11387|MFCD11046372|YIBOMRUWOWDFLG-ONEGZZNKSA-N|EN300-21682062|R278474|R-278474|Rilpivirine [INN]|RILPIVIRINE [JAN]|BCP9000016|S

规格或纯度：≥98%

英文名称：Rilpivirine

生化机理：Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Rilpivirine (R278474) 是一种有效和特异性的二芳基嘧啶 (DAPY) 非核苷逆转录酶抑制剂 (NNRTI)。Rilpivirine 对野生型 HIV (EC50=0.4 nM) 和突变体 (EC50=0.1-2.0 nM) 具有很高的抗病毒活性。Rilpivirine 对 HIV 耐药性的形成产生了高度的遗传障碍。

ALogP：4.5

IUPAC Name：4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile

INCHI：InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

InChi Key：YIBOMRUWOWDFLG-ONEGZZNKSA-N

Canonical SMILES：CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N

Isomeric SMILES：CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N

PubChem CID：6451164

CAS Registry No.：500287-72-9

ChEMBL Ligand：CHEMBL175691

DrugBank Ligand：DB08864

BindingDB Ligand：222178

RCSB PDB Ligand：T27

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P501,P264,P270,P391,P330,P264+P265,P301+P317,P337+P317

产品包装