产品名称

英文名称：Ko 143

同义词

461054-93-3、Ko 143、Ko143、Ko-143、tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2'1,6]pyrido[3,4-b]indol-3-yl)propanoate、CHEMBL488910、(3S,6S,12AS)-1,2,3,4,6,7,12,12A-OCTAHYDRO-9-METHOXY-6-(2-METHYLPROPYL)

产品性质

CAS编号：461054-93-3

分子式：C26H35N3O5·xH2O

分子量：469.57 (anhydrous basis)

MDL号：MFCD19053160

PubChem编号：10322450

英文别名：461054-93-3|Ko 143|Ko143|Ko-143|tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2'1,6]pyrido[3,4-b]indol-3-yl)propanoate|CHEMBL488910|(3S,6S,12AS)-1,2,3,4,6,7,12,12A-OCTAHYDRO-9-METHOXY-6-(2-METHYLPROPYL)

规格或纯度：98%

英文名称：Ko 143

生化机理：Ko 143 is a potent and selective ABCG2 (breast cancer resistance protein multidrμg transporter, BCRP) inhibitor (EC90 = 26 nM). It displays > 200-fold selectivity over P-gp and MRP-1 transporters. Ko 143 also increases intracellular drμg accumulation and reverses BCRP-mediated multidrμg resistance.Potent, selective BCRP inhibitor (EC 50 values are 23 and 26 nM respectively for the export of mitoxantrone and topotecan in cancer cell lines). Non-toxic fumitremorgin C analog.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ko 143是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，EC90为26 nM，比对 P-gp和MRP-1转运通道的抑制性高200倍以上。A selective BCRP multidrμg transporter inhibitorKo 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters.A selective BCRP multidrug transporter inhibitor

IUPAC Name：tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate

INCHI：InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1

InChi Key：NXNRAECHCJZNRF-JBACZVJFSA-N

Canonical SMILES：CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

Isomeric SMILES：CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

WGK Germany：3

PubChem CID：10322450

CAS Registry No.：461054-93-3

溶解性：DMSO >10 mg/mL

密度：1.2

折光率：1.6

沸点：~689.8° C at 760 mmHg

熔点：294.92°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装