产品名称

英文名称：Ethacrynic Acid

同义词

2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid、Edecril、Etacrinic acid、ETACRYNIC ACID [MART.]、Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova、SPBio_000054、[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid、ETHACRYNIC ACID [USAN]、M、依他尼酸

产品性质

CAS编号：58-54-8

分子式：C13H12Cl2O4

分子量：303.14

PubChem编号：3278

别名：依他尼酸

英文别名：2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid|Edecril|Etacrinic acid|ETACRYNIC ACID [MART.]|Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova|SPBio_000054|[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid|ETHACRYNIC ACID [USAN]|M

规格或纯度：≥98%

英文名称：Ethacrynic Acid

储存温度：2-8°C储存,避光

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.A compound classified as a high ceiling diuretic

ALogP：3.8

IUPAC Name：2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid

INCHI：InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChi Key：AVOLMBLBETYQHX-UHFFFAOYSA-N

Canonical SMILES：CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl

Isomeric SMILES：CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl

WGK Germany：1

PubChem CID：3278

DrugBank Ligand：DB00903

CAS Registry No.：58-54-8

ChEMBL Ligand：CHEMBL456

Wikipedia：Ethacrynic acid

ChEBI：CHEBI4876

RCSB PDB Ligand：EAA

DrugCentral Ligand：1071

溶解性：Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water., Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P332+P317,P319

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