产品名称

英文名称：Bufalin

同义词

bufalin、465-21-4、CHEBI517248、3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide、3,14-Dihydroxy-bufa-20,22-dienolide、U549S98QLW、5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one、3bet、3β,14-二羟基-5β、20 (22)-丁二烯醇内酯,5β、20 (22)-丁二烯醇内酯-3β,14-二醇

产品性质

CAS编号：465-21-4

分子式：C24H34O4

分子量：386.52

PubChem编号：9547215

别名：3β,14-二羟基-5β|20 (22)-丁二烯醇内酯,5β|20 (22)-丁二烯醇内酯-3β,14-二醇

英文别名：bufalin|465-21-4|CHEBI517248|3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide|3,14-Dihydroxy-bufa-20,22-dienolide|U549S98QLW|5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one|3bet

规格或纯度：98% (HPLC)

英文名称：Bufalin

生化机理：Na + / K + -ATPase抑制剂。强大的类固醇受体共激活剂SRC-3和SRC-1抑制剂。诱导细胞分化和凋亡。通过JNK激活AP-1。在体内显示抗肿瘤作用。

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis.Bufalin is a cardiotonic steroid[5] and is digoxin-like component of Chan Su.Bufalin has been used• to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)• as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes• to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinibBufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis.Bufalin is a cardiotonic steroid[5] and is digoxin-like component of Chan Su.Bufalin has been used• to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)• as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes• to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib

IUPAC Name：5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

INCHI：InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1

InChi Key：QEEBRPGZBVVINN-BMPKRDENSA-N

Canonical SMILES：CC12CCC(CC1CCC3C2CCC4(C3(CCC4C5=COC(=O)C=C5)O)C)O

Isomeric SMILES：C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O

WGK Germany：3

RTECS：EI2962500

PubChem CID：9547215

溶解性：DMF soluble；DMSO soluble；ethanol soluble

敏感性：对光敏感

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

产品包装