产品名称

英文名称：TG100-115

同义词

TG100-115、677297-51-7、3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol、6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine、TG-100115、3,3'-(2,4-DIAMINO-6,7-PTERIDINEDIYL)BISPHENOL、TG-100-115、3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol、TG 100115、TG 100-115

产品性质

CAS编号：677297-51-7

分子式：C18H14N6O2

分子量：346.35

PubChem编号：10427712

英文别名：TG100-115|677297-51-7|3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol|6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine|TG-100115|3,3'-(2,4-DIAMINO-6,7-PTERIDINEDIYL)BISPHENOL|TG-100-115|3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol|TG 100115|TG 100-115

规格或纯度：≥98%

英文名称：TG100-115

生化机理：TG100-115 inhibits PI 3-kinase p110 γ and PI 3-kinase p110 δ (PI3Kγ and -δ), with IC50 of 83 and 235 nM, respectively. TG100-115 is not active for PI3Kα and -β, with IC50 of 1.2 and 1.3 mM. TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR, also known as FRAP, and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：TG100-115是PI3K γ和δ抑制剂，IC50分别为83和235 nM。A PI3K and FRAP inhibitor with some action against AktTG100-115 is a PI3K γ and -δ inhibitor (IC50 = 83 and 235 nM, respectively).A PI3K and FRAP inhibitor with some action against Akt

ALogP：1.7

IUPAC Name：3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol

INCHI：InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)

InChi Key：UJIAQDJKSXQLIT-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N

Isomeric SMILES：C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N

PubChem CID：10427712

CAS Registry No.：677297-51-7

DiscoveRx TREEspot：TG-100-115|

ChEMBL Ligand：CHEMBL230011

RCSB PDB Ligand：B6J

溶解性：DMSO 9 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装