产品名称

英文名称：WZ3146

同义词

1214265-56-1、WZ3146、WZ-3146、N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide、WZ 3146、N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide、N-[3-[5-chloro-2-[4-(4-

产品性质

CAS编号：1214265-56-1

分子式：C24H25ClN6O2

分子量：464.96

PubChem编号：44607360

英文别名：1214265-56-1|WZ3146|WZ-3146|N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide|WZ 3146|N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide|N-[3-[5-chloro-2-[4-(4-

规格或纯度：≥98%

英文名称：WZ3146

生化机理：WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：WZ3146是不可逆的EGFR(L858R)和EGFR(E746_A750)突变选择型抑制剂，IC50均为2 nM，对ERBB2磷酸化(T798I)无抑制性。A mutant EGFR phosphorylation inhibitorWZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).A mutant EGFR phosphorylation inhibitor

IUPAC Name：N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

INCHI：InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

InChi Key：APHGZZPEOCCYNO-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

Isomeric SMILES：CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

PubChem CID：44607360

溶解性：DMSO 93 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装