产品名称

英文名称：AZD8330

同义词

AZD8330、869357-68-6、AZD-8330、ARRY-424704、ARRY-704、AZD 8330、2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide、2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-

产品性质

CAS编号：869357-68-6

分子式：C16H17FIN3O4

分子量：461.23

PubChem编号：16666708

英文别名：AZD8330|869357-68-6|AZD-8330|ARRY-424704|ARRY-704|AZD 8330|2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide|2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-

规格或纯度：≥98%

英文名称：AZD8330

生化机理：AZD8330 potently and strongly inhibits MEK 1/2. AZD8330 has no inhibitory activity against over 200 other kinases including at concentrations up to 10 μM. AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines.A selective allosteric MEK inhibitor. Orally active. IC 50 of 7 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic,\xa0refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

产品介绍：AZD8330(ARRY-424704; ARRY-704)是非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。An antineoplastic selective MEK inhibitorAZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.An antineoplastic selective MEK inhibitor

ALogP：2.2

IUPAC Name：2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide

INCHI：InChI=1S/C16H17FIN3O4/c1-9-7-11(15(23)20-25-6-5-22)14(21(2)16(9)24)19-13-4-3-10(18)8-12(13)17/h3-4,7-8,19,22H,5-6H2,1-2H3,(H,20,23)

InChi Key：RWEVIPRMPFNTLO-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

Isomeric SMILES：CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

PubChem CID：16666708

ChEMBL Ligand：CHEMBL3182621

CAS Registry No.：869357-68-6

溶解性：DMSO 92 mg/mL Water <1 mg/mL Ethanol 92 mg/mL

密度：1.73

折光率：1.66

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P321,P405,P501,P264,P260,P270,P330,P301+P316,P319

产品包装