产品名称

英文名称：MK-1775

同义词

MK-1775、955365-80-7、Adavosertib、MK1775、AZD1775、MK 1775、AZD-1775、AZD 1775、1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one、2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-m

产品性质

CAS编号：955365-80-7

分子式：C27H32N8O2

分子量：500.61

PubChem编号：24856436

英文别名：MK-1775|955365-80-7|Adavosertib|MK1775|AZD1775|MK 1775|AZD-1775|AZD 1775|1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one|2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-m

规格或纯度：98%

英文名称：MK-1775

生化机理：MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM.Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC 50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：产品介绍MK-1775是Wee1的有效选择性抑制剂，无细胞试验中IC50为5.2 nM。MK-1775通过磷酸化Tyr15残基消除细胞周期蛋白依赖性激酶1（CDC2）的活性。Wee1是属于Ser/Thr蛋白激酶家族的核激酶。Wee1激酶通过催化CDC2/cyclin B激酶的抑制性酪氨酸磷酸化，负向调节进入有丝分裂。Wee1的功能紊乱导致小于正常的子细胞的生成。

ALogP：3.1

IUPAC Name：1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one

INCHI：InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)

InChi Key：BKWJAKQVGHWELA-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O

Isomeric SMILES：CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O

PubChem CID：24856436

CAS Registry No.：955365-80-7

ChEMBL Ligand：CHEMBL1976040

RCSB PDB Ligand：8X7

溶解性：DMSO 80 mg/mL Water 0.0001 mg/mL Ethanol <1 mg/mL

产品包装