产品名称

英文名称：MLN9708

同义词

1201902-80-8、MLN-9708、4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid、133876-92-3、MLN 9708、Ixazomib Citrate (MLN9708)、4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]ac、柠檬酸伊沙佐米

产品性质

CAS编号：1201902-80-8

分子式：C20H23BCl2N2O9

分子量：517.12

PubChem编号：49867936

别名：柠檬酸伊沙佐米

英文别名：1201902-80-8|MLN-9708|4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid|133876-92-3|MLN 9708|Ixazomib Citrate (MLN9708)|4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]ac

规格或纯度：≥98%

英文名称：MLN9708

生化机理：MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、10mg、100mg卖完停产，不再备货

产品介绍：MLN9708 immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM.MLN9708在水溶液或血浆中立即水解为具有具有生物活性的MLN2238。MLN2238抑制20S proteasome的胰凝乳蛋白酶等蛋白水解位点（β5），无细胞试验中IC50/Ki为3.4 nM/0.93 nM，对β1作用效果稍弱，对β2几乎没有抑制活性。

IUPAC Name：4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

INCHI：InChI=1S/C20H23BCl2N2O9/c1-10(2)5-14(21-33-17(29)8-20(34-21,19(31)32)7-16(27)28)25-15(26)9-24-18(30)12-6-11(22)3-4-13(12)23/h3-4,6,10,14H,5,7-9H2,1-2H3,(H,24,30)(H,25,26)(H,27,28)(H,31,32)/t14-,20?/m0/s1

InChi Key：YTXSYWAKVMZICI-PVCZSOGJSA-N

Canonical SMILES：B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl

Isomeric SMILES：B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl

PubChem CID：49867936

溶解性：DMSO 103 mg/mL Water Ethanol

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338

产品包装