产品名称

英文名称：STF-62247

同义词

STF-62247、315702-99-9、Autophagy Inducer, STF-62247、4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine、N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine、4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine、STF62247、STF 62247、N-(3-methylphenyl)-4-(pyridin-4-yl)-1,3-thiaz

产品性质

CAS编号：315702-99-9

分子式：C15H13N3S

分子量：267.35

MDL号：MFCD01121974

PubChem编号：704473

英文别名：STF-62247|315702-99-9|Autophagy Inducer, STF-62247|4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine|N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine|4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine|STF62247|STF 62247|N-(3-methylphenyl)-4-(pyridin-4-yl)-1,3-thiaz

规格或纯度：≥98%

英文名称：STF-62247

生化机理：Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). Selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 μM in RCC4 and RCC4/VHL killing, respectively) and in mice. Althoμgh STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：STF-62247是一个TGN抑制剂，在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。STF-62247 may be used as positive control in autophagy inducing cell signaling studies.STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

IUPAC Name：N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

INCHI：InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChi Key：KATNUHQNJGNLPW-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3

Isomeric SMILES：CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3

WGK Germany：2

PubChem CID：704473

溶解性：DMSO 53 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

密度：1.26

折光率：1.67

沸点：444.82° C

熔点：174.66°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装