产品名称

英文名称：FG-4592

同义词

FG-4592 (ASP1517)、NCGC00346527-01、NCGC00346527-07、N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine、Roxadustat、YOZBGTLTNGAVFU-UHFFFAOYSA-N、2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid、Evrenzo、J-522733、3-chloro-2-hy、罗沙司他

产品性质

CAS编号：808118-40-3

分子式：C19H16N2O5

分子量：352.34

PubChem编号：11256664

别名：罗沙司他

英文别名：FG-4592 (ASP1517)|NCGC00346527-01|NCGC00346527-07|N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine|Roxadustat|YOZBGTLTNGAVFU-UHFFFAOYSA-N|2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid|Evrenzo|J-522733|3-chloro-2-hy

规格或纯度：≥98%

英文名称：FG-4592

生化机理：FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：FG-4592是一种HIF α脯氨酰羟化酶抑制剂，并能稳定HIF-2，同时诱导EPO产生。FG-4592 is an HIF α prolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production.

ALogP：3.4

IUPAC Name：2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid

INCHI：InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)

InChi Key：YOZBGTLTNGAVFU-UHFFFAOYSA-N

Canonical SMILES：CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3

Isomeric SMILES：CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3

PubChem CID：11256664

CAS Registry No.：808118-40-3

ChEMBL Ligand：CHEMBL2338329

RCSB PDB Ligand：8HO

DrugCentral Ligand：5371

溶解性：DMSO >70 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH332 Harmful if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P332+P317,P319

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