产品名称

英文名称：CCT128930

同义词

CCT128930、885499-61-6、4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine、CCT-128930、CCT 128930、4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine、CHEMBL263664、4-[(4-chlorophenyl)methyl]-1-{7H-pyrrolo[2,3-d

产品性质

CAS编号：885499-61-6

分子式：C18H20ClN5

分子量：341.84

PubChem编号：17751819

英文别名：CCT128930|885499-61-6|4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine|CCT-128930|CCT 128930|4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine|CHEMBL263664|4-[(4-chlorophenyl)methyl]-1-{7H-pyrrolo[2,3-d

规格或纯度：98%

英文名称：CCT128930

生化机理：CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. CCT128930 showed significantly antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. CCT128930 caused a G1 arrest in PTEN- U87MG human glioblastoma cells, in good agreement with AKT pathway blockade.Potent\xa0and selective AKT2 inhibitor (IC50= 6 nM) with selectivity greater than 28-fold and 20-fold over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM), respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍CCT128930 是一种 ATP 竞争性地且选择性的 AKT 抑制剂 (对AKT2 的 IC50 为 6 nM )。CCT128930 通过靶向 AKT 的 Met282 (PKA-AKT嵌合体的 Met173)，对 PKA 激酶 (IC50=168 nM) 具有 28 倍的选择性，对 p70S6K (IC50=120 nM) 具有 20 倍的选择性。具有抗肿瘤活性。

IUPAC Name：4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine

INCHI：InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)

InChi Key：RZIDZIGAXXNODG-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4

Isomeric SMILES：C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4

PubChem CID：17751819

溶解性：DMSO 68 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

产品包装