产品名称

英文名称：SGI-1776 free base

同义词

SGI-1776、1025065-69-3、SGI-1776 free base、N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine、SGI1776、N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine、SGI 1776、N-[

产品性质

CAS编号：1025065-69-3

分子式：C20H22F3N5O

分子量：405.42

PubChem编号：24795070

英文别名：SGI-1776|1025065-69-3|SGI-1776 free base|N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine|SGI1776|N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine|SGI 1776|N-[

规格或纯度：≥98%

英文名称：SGI-1776 free base

生化机理：SGI-1776 is a novel ATP-competitive inhibitor of Pim-1, Pim-2, and Pim-3 (IC50 = 7, 363, and 69 nM, respectively). In addition to inhibiting Pim, this compound also inhibits FLT3 (IC50 = 44 nM). SGI-1776 is also cytotoxic in AML primary cells, regardless of the FLT3 mutation status, which results in Mcl-1 protein decline. SGI-1776 inhibits tumor growth for intermediate EFS T/C activity in 1 of 39 evaluable models.Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SGI-1776 free base是一种新型的，ATP竞争性的Pim1抑制剂，IC50为7 nM，比作用于Pim2和Pim3选择性分别高50和10倍，作用于Flt3和haspin也有效。A potent apoptotic that targets Pim and FLT3 in AML and CLL cells.SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspinA potent apoptotic that targets Pim and FLT3 in AML and CLL cells.

IUPAC Name：N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

INCHI：InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)

InChi Key：MHXGEROHKGDZGO-UHFFFAOYSA-N

Canonical SMILES：CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

Isomeric SMILES：CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

PubChem CID：24795070

CAS Registry No.：1025065-69-3

ChEMBL Ligand：CHEMBL1952329

溶解性：DMSO ≥80mg/mL Water <1.2mg/mL Ethanol ≥80mg/mL

产品包装