产品名称

英文名称：ARRY-520

同义词

Filanesib、ARRY-520、885060-09-3、Filanesib [INN]、ARRY 520、Arry520、Filanesib(ARRY-520)、(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide、CHEMBL2347655、8A49OSO368、885060-09-3 (free base)、1,3,4-Thiadi

产品性质

CAS编号：885060-09-3

分子式：C20H22F2N4O2S

分子量：420.48

PubChem编号：44224257

英文别名：Filanesib|ARRY-520|885060-09-3|Filanesib [INN]|ARRY 520|Arry520|Filanesib(ARRY-520)|(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide|CHEMBL2347655|8A49OSO368|885060-09-3 (free base)|1,3,4-Thiadi

规格或纯度：98%

英文名称：ARRY-520

生化机理：ARRY-520 is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：3.3

IUPAC Name：(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide

INCHI：InChI=1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1

InChi Key：LLXISKGBWFTGEI-FQEVSTJZSA-N

Canonical SMILES：CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC

Isomeric SMILES：CN(C(=O)N1[C@](SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC

PubChem CID：44224257

溶解性：DMSO

产品包装