产品名称

英文名称：Binimetinib

同义词

Binimetinib、606143-89-9、MEK162、ARRY-162、Mektovi、ARRY-438162、MEK-162、5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide、NVP-MEK162、binimetinibum、ARRY 162、Binimetinib (MEK-162)、ARRY 438162、UNII-181R97MR71、5-[(4-溴-2-氟苯基)氨基]-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并咪唑-6-甲酰胺

产品性质

CAS编号：606143-89-9

分子式：C17H15BrF2N4O3

分子量：441.23

PubChem编号：10288191

别名：5-[(4-溴-2-氟苯基)氨基]-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并咪唑-6-甲酰胺

英文别名：Binimetinib|606143-89-9|MEK162|ARRY-162|Mektovi|ARRY-438162|MEK-162|5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide|NVP-MEK162|binimetinibum|ARRY 162|Binimetinib (MEK-162)|ARRY 438162|UNII-181R97MR71|

规格或纯度：98%

英文名称：Binimetinib

生化机理：MEK162(ARRY-162; ARRY-438162) is an oral, highly selective MEK inhibitor. MEK162(ARRY-162; ARRY-438162) is now being investigated in Phase I trials in advanced solid tumors.Potent and selective allosteric inhibitor of MEK1/2. Orally bioavailable.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

ALogP：3.1

IUPAC Name：6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide

INCHI：InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChi Key：ACWZRVQXLIRSDF-UHFFFAOYSA-N

Canonical SMILES：CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

Isomeric SMILES：CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

PubChem CID：10288191

CAS Registry No.：606143-89-9

Wikipedia：Binimetinib

ChEMBL Ligand：CHEMBL3187723

Reactome Reaction：R-HSA-9657606

Reactome Drug：R-ALL-9657530

RCSB PDB Ligand：QO7

DrugCentral Ligand：5290

溶解性：DMSO 88 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H317 May cause an allergic skin reactionH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P263,P203,P318,P319

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