产品名称

英文名称：WP1066

同义词

WP1066、857064-38-1、(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide、WP 1066、WP-1066、wp1066STAT Inhibitor III、63V8AIE65T、2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-、UNII-63V8AIE65T、MLS006010178、GTPL7972、SC

产品性质

CAS编号：857064-38-1

分子式：C17H14BrN3O

分子量：356.22

PubChem编号：11210478

英文别名：WP1066|857064-38-1|(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide|WP 1066|WP-1066|wp1066STAT Inhibitor III|63V8AIE65T|2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-|UNII-63V8AIE65T|MLS006010178|GTPL7972|SC

规格或纯度：≥98%

英文名称：WP1066

生化机理：WP1066 (WP10666) is a cell permeable AG 490 tyrphostin analog that effectively inhibits the STAT3 pathway. The inhibitor is a potent antitumor agent as displayed in the growth inhibition of malignant glioma cell and acute myelogenous leukemia cells. Stat3 Inhibitor III, WP1066 has shown more potency as an antitumor agent than AG 490 when inhibiting malignant glioma growth in vitro. WP1066 also acts as an immune adjuvant by inducing proliferation of effector T cells and upregulating CD86 and CD80. In addition WP1066 has displayed inhibition of JAK2 protein tyrosine kinase as well as sμggested activation of Bax.JAK/STAT3 inhibitor (IC 50 = 2.3 μM). More potent analog of AG 490 . Antitumor activity in vitro and in vivo . Cell-permeable. Blood-brain barrier permeable.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：WP1066是一种新型JAK2和STAT3抑制剂，在HEL细胞中IC50分别为2.30 μM和2.43 μM；对JAK2，STAT3，STAT5和ERK1/2具有抑制活性，而对JAK1和JAK3没有作A cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase.WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3.A cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase.

PubChem SID：488197282

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488197282

IUPAC Name：(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

INCHI：InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

InChi Key：VFUAJMPDXIRPKO-LQELWAHVSA-N

Canonical SMILES：CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

Isomeric SMILES：C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

PubChem CID：11210478

CAS Registry No.：857064-38-1

ChEMBL Ligand：CHEMBL1923234

溶解性：DMSO 72 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装