产品名称

英文名称：AST-1306

同义词

AST-1306、Allitinib、897383-62-9、AST1306、AST 1306、N-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide、ALS 1306、CX0M5RO7CY、ALL-3、897383-62-9 (free base)、n-(4-((3-chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-2-propena

产品性质

CAS编号：897383-62-9

分子式：C24H18ClFN4O2

分子量：448.88

PubChem编号：24739943

英文别名：AST-1306|Allitinib|897383-62-9|AST1306|AST 1306|N-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide|ALS 1306|CX0M5RO7CY|ALL-3|897383-62-9 (free base)|n-(4-((3-chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-2-propena

规格或纯度：98%

英文名称：AST-1306

生化机理：AST-1306 functions as an irreversible inhibitor, most likely throμgh covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. Further studies showed that AST-1306 inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. AST-1306 is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST-1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST-1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AST 1306是EGFR和HER2的新型抑制剂，IC50分别为0.5 nM和3 nM。 表皮生长因子受体（EGFR）是一种细胞表面受体酪氨酸激酶。受体活化导致二聚化和酪氨酸自磷酸化。它诱导一系列下游细胞应答级联反应，如基因表达修饰、细胞增殖和细胞骨架重排等。HER2是表皮生长因子的一员，与乳腺癌和卵巢癌有关。 在无细胞实验中，AST1306选择性阻断EGFR和HER2激酶的活性。在完整的细胞和无细胞实验中，AST1306可以抑制EGFR突变T790M/L858R的酪氨酸激酶活性。此外，AST1306减弱EGFR和HER2的磷酸化和下游底物。 在ErbB2过表达的异种移植小鼠模型和FVB-2/Nneu转基因小鼠模型中，AST1306有效抑制肿瘤生长。在SK-OV-3异种移植模型中，AST1306对EGFR和HER2产生了快速和长效的抑制，大于等于24h。

ALogP：5.4

IUPAC Name：N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide

INCHI：InChI=1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12,14H,1,13H2,(H,29,31)(H,27,28,30)

InChi Key：MVZGYPSXNDCANY-UHFFFAOYSA-N

Canonical SMILES：C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

Isomeric SMILES：C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

关联CAS：897383-62-9

PubChem CID：24739943

MeSH Entry Terms：allitinib;AST 1306;AST-1306;AST1306;N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-quinazolinyl)acrylamide

溶解性：≥22.45 mg/mL二甲基亚砜溶液；不溶于水；不溶于乙醇

产品包装