产品名称

英文名称：Rocilinostat (ACY-1215)

同义词

1316214-52-4、Ricolinostat、ACY-1215、Rocilinostat、2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide、Rocilinostat (ACY-1215)、ACY-63、Ricolinostat (ACY-1215)、N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

产品性质

CAS编号：1316214-52-4

分子式：C24H27N5O3

分子量：433.5

PubChem编号：53340666

英文别名：1316214-52-4|Ricolinostat|ACY-1215|Rocilinostat|2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide|Rocilinostat (ACY-1215)|ACY-63|Ricolinostat (ACY-1215)|N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide|

规格或纯度：≥98%

英文名称：Rocilinostat (ACY-1215)

生化机理：ACY-1215 is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system throμgh hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Rocilinostat (ACY-1215)是一种选择性HDAC6抑制剂， IC50为5 nM，作用于HDAC6比作用于HDAC1/2/3(I型HDACs)选择性高10倍以上，对HDAC8具有微弱的作用活性，对HDAC4/5/7/9/11， Sirtuin1和Sirtuin2具有最低限度的作用活性。Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.

ALogP：3.4

PubChem SID：488201578

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488201578

IUPAC Name：N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

INCHI：InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)

InChi Key：QGZYDVAGYRLSKP-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

Isomeric SMILES：C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

PubChem CID：53340666

CAS Registry No.：1316214-52-4

ChEMBL Ligand：CHEMBL2364628

RCSB PDB Ligand：AH4

溶解性：DMSO 87 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装