产品名称

英文名称：Reparixin

同义词

reparixin、repertaxin、266359-83-5、DF 1681Y、(R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propanamide、DF1681Y、Reparixin (Repertaxin)、DF-1681Y、CHEMBL191413、U604E1NB3K、DTXSID6046509、266359-83-5 (free base)、Reparixin [INN]、(2R)-2-[4-(2-methylpropyl)phenyl]-N-meth

产品性质

CAS编号：266359-83-5

分子式：C14H21NO3S

分子量：283.39

PubChem编号：9838712

英文别名：reparixin|repertaxin|266359-83-5|DF 1681Y|(R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propanamide|DF1681Y|Reparixin (Repertaxin)|DF-1681Y|CHEMBL191413|U604E1NB3K|DTXSID6046509|266359-83-5 (free base)|Reparixin [INN]|(2R)-2-[4-(2-methylpropyl)phenyl]-N-meth

规格或纯度：≥98%

英文名称：Reparixin

生化机理：The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 uM for CXCR1 weight and CXCR1 Ile43Val, respectively). Treatment with reparixin significantly counteracts secondary degeneration by reducing oligodendrocyte apoptosis, migration to the injury site of neutrophils and ED-1-positive cells。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Reparixin(DF 1681Y)是CXCL8受体抑制剂，同时还能抑制CXCR1和CXCR2的活性，能减低多种损伤模型中的炎症反应。Reparixin(DF 1681Y) is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.

ALogP：2.9

IUPAC Name：(2R)-2-[4-(2-methylpropyl)phenyl]-N-methylsulfonylpropanamide

INCHI：InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1

InChi Key：KQDRVXQXKZXMHP-LLVKDONJSA-N

Canonical SMILES：CC(C)CC1=CC=C(C=C1)C(C)C(=O)NS(=O)(=O)C

Isomeric SMILES：C[C@H](C1=CC=C(C=C1)CC(C)C)C(=O)NS(=O)(=O)C

PubChem CID：9838712

ChEMBL Ligand：CHEMBL191413

CAS Registry No.：266359-83-5

GPCRdb Ligand：reparixin

溶解性：25°C DMSO

比旋光度：（α/D -80 to -90°, c = 1.0 in ethanol）

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装