产品名称

英文名称：PluriSIn #1 (NSC 14613)

同义词

PluriSln 1、91396-88-2、N'-phenylisonicotinohydrazide、plurisin 1、N'-phenylpyridine-4-carbohydrazide、NSC 14613、PluriSIn #1、PluriSIn #1 (NSC 14613)、PluriSln 1(NSC 14613)、4-Pyridinecarboxylic acid 2-phenylhydrazide、PluriSln-1 (NSC 14613)、C12H11N3O、MFCD02344904、4-吡啶羧酸 2-苯基酰肼

产品性质

CAS编号：91396-88-2

分子式：C12H11N3O

分子量：213.24

MDL号：MFCD02344904

PubChem编号：225362

别名：4-吡啶羧酸 2-苯基酰肼

英文别名：PluriSln 1|91396-88-2|N'-phenylisonicotinohydrazide|plurisin 1|N'-phenylpyridine-4-carbohydrazide|NSC 14613|PluriSIn #1|PluriSIn #1 (NSC 14613)|PluriSln 1(NSC 14613)|4-Pyridinecarboxylic acid 2-phenylhydrazide|PluriSln-1 (NSC 14613)|C12H11N3O|MFCD02344904

规格或纯度：≥98%

英文名称：PluriSIn #1 (NSC 14613)

生化机理：PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic reticulum stress, reduces protein synthesis, and prevents teratoma formation in immunocompromised mice models.Selective stearoyl-CoA desaturase-1 (SCD1) inhibitor. Inhibits oleic acid biosynthesis. Induces apoptosis. Decreases Nanog expression. Selectively eliminates undifferentiated embryonic stem cells. Shows cytotoxic effects.

应用：A SCD1 inhibitor and apoptosis inducer.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PluriSIn #1 (NSC 14613)是一种stearoyl-coA desaturase 1 (SCD1)抑制剂，选择性消除hPSCs。A SCD1 inhibitor and apoptosis inducer.PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCsA SCD1 inhibitor and apoptosis inducer.

IUPAC Name：N'-phenylpyridine-4-carbohydrazide

INCHI：InChI=1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)

InChi Key：HUDWXDLBWRHCKO-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2

Isomeric SMILES：C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2

WGK Germany：3

PubChem CID：225362

溶解性：DMSO 43 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

熔点：189 °C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

产品包装