产品名称

英文名称：TIC10 Analogue

同义词

41276-02-2、TIC 10、TIC-10、TIC10、7-Benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one、TIC-10 Isomer、NSC350625、41276-02-2 (TIC10 isomer)、7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-

产品性质

CAS编号：41276-02-2

分子式：C24H26N4O

分子量：386.49

PubChem编号：336423

英文别名：41276-02-2|TIC 10|TIC-10|TIC10|7-Benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one|TIC-10 Isomer|NSC350625|41276-02-2 (TIC10 isomer)|7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-

规格或纯度：≥98%

英文名称：TIC10 Analogue

生化机理：TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent.TRAIL activator. Induces TRAIL via Akt and ERK inactivation. Induces apoptosis in cancer cells and healthy cells. Shows antitumor effects in vivo. Blood-brain barrier permeable.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍TIC10（TRAIL诱导型化合物10）是一种有效的和稳定的小分子，具有口服活性。它诱导TRAIL转录不依赖的p53，可穿过血脑屏障。Product DescribtionTIC10 (TRAIL-inducing compound 10) is a potent and stable small molecule that is orally active. It induces TRAIL transcriptionally independent of p53 and crosses the blood-brain barrier.

IUPAC Name：11-benzyl-2-[(2-methylphenyl)methyl]-2,4,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3-dien-8-one

INCHI：InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-22-11-13-26(15-19-8-3-2-4-9-19)17-21(22)23(29)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3

InChi Key：RSAQARAFWMUYLL-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5

Isomeric SMILES：CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5

PubChem CID：336423

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL

产品包装