产品名称

英文名称：GZD824 Dimesylate

同义词

GZD824 Dimesylate、1421783-64-3、GZD824、GZD-824 Dimesylate、Olverembatinib (dimesylate)、D-824 dimesylate、NPJ9AW8AZR、methanesulfonic acid;4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]be

产品性质

CAS编号：1421783-64-3

分子式：C31H35F3N6O7S2

分子量：724.77

PubChem编号：71519689

英文别名：GZD824 Dimesylate|1421783-64-3|GZD824|GZD-824 Dimesylate|Olverembatinib (dimesylate)|D-824 dimesylate|NPJ9AW8AZR|methanesulfonic acid;4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]be

规格或纯度：98%

英文名称：GZD824 Dimesylate

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Olverembatinib dimesylate (HQP1351, GZD824)是新型口服有效的Bcr-Abl抑制剂，作用于Bcr-Abl(WT)和Bcr-Abl(T315I)，IC50分别为0.34 nM和0.68 nM。

IUPAC Name：methanesulfonic acid;4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

INCHI：InChI=1S/C29H27F3N6O.2CH4O3S/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38;2*1-5(2,3)4/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36);2*1H3,(H,2,3,4)

InChi Key：LEVIGHXVOVROGW-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4.CS(=O)(=O)O.CS(=O)(=O)O

Isomeric SMILES：CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4.CS(=O)(=O)O.CS(=O)(=O)O

PubChem CID：71519689

溶解性：DMSO 100 mg/mL Water 100 mg/mL Ethanol <1 mg/mL

敏感性：对光线、湿度敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338

产品包装