产品名称

英文名称：Gilteritinib

同义词

Gilteritinib、1254053-43-4、ASP2215、ASP-2215、Xospata、gilteritinibum、ASP 2215、UNII-66D92MGC8M、66D92MGC8M、Gilteritinib(ASP2215)、6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carb

产品性质

CAS编号：1254053-43-4

分子式：C29H44N8O3

分子量：552.7115

PubChem编号：49803313

英文别名：Gilteritinib|1254053-43-4|ASP2215|ASP-2215|Xospata|gilteritinibum|ASP 2215|UNII-66D92MGC8M|66D92MGC8M|Gilteritinib(ASP2215)|6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carb

规格或纯度：97%

英文名称：Gilteritinib

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Gilteritinib 是小分子FLT3/AXL抑制剂，对FLT3和AXL的IC50值为0.29 nM和0.73 nM。其抑制c-KIT的IC50值约为抑制FLT3的800倍。product descriptionGilteritinib (ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).

ALogP：3.5

IUPAC Name：6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide

INCHI：InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

InChi Key：GYQYAJJFPNQOOW-UHFFFAOYSA-N

Canonical SMILES：CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5

Isomeric SMILES：CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5

PubChem CID：49803313

ChEMBL Ligand：CHEMBL3301622

CAS Registry No.：1254053-43-4

RCSB PDB Ligand：C6F

Reactome Reaction：R-HSA-9702508, R-HSA-9695828, R-HSA-9702589

Reactome Drug：R-ALL-9695700

DrugCentral Ligand：5306

产品包装