产品名称

英文名称：Delavirdine

同义词

Delavirdine、136817-59-9、Rescriptor、Delavirdine [INN]、u-90152、N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide、U 90152、Delavirdine (INN)、2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-me

产品性质

CAS编号：136817-59-9

分子式：C22H28N6O3S

分子量：456.56

PubChem编号：5625

英文别名：Delavirdine|136817-59-9|Rescriptor|Delavirdine [INN]|u-90152|N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide|U 90152|Delavirdine (INN)|2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-me

规格或纯度：98%

英文名称：Delavirdine

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).1 It inhibits growth of clinical isolates of HIV-1 (ED50s = <0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).2 Formulations containing delavirdine have been used in the treatment of HIV.

IUPAC Name：N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide

INCHI：InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3

InChi Key：WHBIGIKBNXZKFE-UHFFFAOYSA-N

Canonical SMILES：CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C

Isomeric SMILES：CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C

PubChem CID：5625

溶解性：25°C DMSO

产品包装