产品名称

英文名称：Camostat Mesilate

同义词

Camostat mesylate、camostat mesilate、59721-29-8、Camostat (mesylate)、Camostat Methanesulfonate、Foipan、camostate、MFCD00941410、FOY305、Camostat mesilate [JAN]、DTXSID0020238、Camostat mesilate;FOY305;FOY-S980、4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)pheny、甲磺酸卡莫司他、FOY305

产品性质

CAS编号：59721-29-8

分子式：C20H22N4O5.CH4O3S

分子量：494.52

MDL号：MFCD00941410

PubChem编号：5284360

别名：甲磺酸卡莫司他|FOY305

英文别名：Camostat mesylate|camostat mesilate|59721-29-8|Camostat (mesylate)|Camostat Methanesulfonate|Foipan|camostate|MFCD00941410|FOY305|Camostat mesilate [JAN]|DTXSID0020238|Camostat mesilate;FOY305;FOY-S980|4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)pheny

规格或纯度：≥98%

英文名称：Camostat Mesilate

生化机理：Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC 50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic st

应用：A protease and Trypsin inhibitor.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Camostat Mesilate是胰蛋白酶样的蛋白酶抑制剂，抑制上皮细胞钠离子通道(ENaC)功能，IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。A protease and Trypsin inhibitor.Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.A protease and Trypsin inhibitor.

IUPAC Name：[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid

INCHI：InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

InChi Key：FSEKIHNIDBATFG-UHFFFAOYSA-N

Canonical SMILES：CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O

Isomeric SMILES：CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O

WGK Germany：3

关联CAS：59721-28-7（free）

PubChem CID：5284360

溶解性：Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

熔点：164-168°

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH400 Very toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P391,P264+P265,P337+P317,P332+P317,P319

Merck Index：1728

产品包装