产品名称

英文名称：Tyrphostin AG 879

同义词

Tyrphostin AG 879、148741-30-4、AG 879、AG-879、AG879、alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide、Tyrphostin Ag-879、(2E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide、(E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioam

产品性质

CAS编号：148741-30-4

分子式：C18H24N2OS

分子量：316.46

MDL号：MFCD00236450

PubChem编号：135419190

英文别名：Tyrphostin AG 879|148741-30-4|AG 879|AG-879|AG879|alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide|Tyrphostin Ag-879|(2E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide|(E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioam

规格或纯度：≥98%

英文名称：Tyrphostin AG 879

生化机理：Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1.Selective TrkA receptor inhibitor. Inhibits NGF-dependent TrkA phosphorylation (IC 50 = 40 μM). Additionally inhibits ErbB2 and the VEGF receptor FLK-1 (IC 50 = ~1 μM). Active in vitro and in vivo . Shows antitumor activity.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。A protein tyrosine kinase inhibitor with potent effects on TrkATyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 μmol/L) than EGFR (IC50 >500 μmol/L).A protein tyrosine kinase inhibitor with potent effects on TrkA

IUPAC Name：(E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enethioamide

INCHI：InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

InChi Key：XRZYELWZLNAXGE-KPKJPENVSA-N

Canonical SMILES：CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C(=S)N

Isomeric SMILES：CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)/C=C(\C#N)/C(=S)N

WGK Germany：3

PubChem CID：135419190

CAS Registry No.：148741-30-4

ChEMBL Ligand：CHEMBL539947

溶解性：DMSO 36 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

折光率：1.61

沸点：~443.81° C at 760 mmHg

熔点：219-220°C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装