产品名称

英文名称：WAY-100635 maleate salt

同义词

WAY-100635 maleate salt、WAY-100635 maleate、1092679-51-0、634908-75-1、WAY 100635 maleate、WAY100635、WAY-100635 (maleate salt)、N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide maleate、WAY100635 Maleate、n-[2-[4-(2-methoxyph、N- [2- [4-(2-甲氧基苯基)-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺 马来酸盐

产品性质

CAS编号：634908-75-1

分子式：C25H34N4O2 · C4H4O4

分子量：538.64

MDL号：MFCD01321056

PubChem编号：11957721

别名：N- [2- [4-(2-甲氧基苯基)-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺 马来酸盐

英文别名：WAY-100635 maleate salt|WAY-100635 maleate|1092679-51-0|634908-75-1|WAY 100635 maleate|WAY100635|WAY-100635 (maleate salt)|N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide maleate|WAY100635 Maleate|n-[2-[4-(2-methoxyph

规格或纯度：98%

英文名称：WAY-100635 maleate salt

生化机理：WAY-100635 maleate salt is a potent, selective and high affinity SR-2B antagonist with a pIC50 of 10.4. The affinity (pKi) of WAY-100635 maleate salt for tSR-2B is 9.5. In addition, WAY-100635 maleate salt also blocks serotonin-evoked contraction of rat isolated stomach fundus.Potent, selective, silent 5-HT 1A receptor antagonist (IC 50 = 1.35 nM). Displays >100-fold selectivity for 5-HT 1A relative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels.

应用：WAY-100635 maleate salt has been used as a 5-HT1A serotonin receptor antagonist · to study whether the behavior of the cleaner wrasse is regulated by serotonin activity · to block activity of 3,4 methylenedioxymethamphetamine (MDMA) used to induce oxytocin release in male Wistar rats to increase their social behavior · to study the role of serotonin during metamorphosis of the ascidian Phallusia mammillata larvae

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：WAY-100635马来酸盐是5-HT受体拮抗剂，IC50为0.95nMWAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT.

IUPAC Name：(Z)-but-2-enedioic acid;N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide

INCHI：InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChi Key：XIGAHNVCEFUYOV-BTJKTKAUSA-N

Canonical SMILES：COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.C(=CC(=O)O)C(=O)O

Isomeric SMILES：COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.C(=C\C(=O)O)\C(=O)O

PubChem CID：11957721

溶解性：H2O 25 mg/mL

产品包装