产品名称

英文名称：N-tert-Butyl-α-phenylnitrone

同义词

n-tert-butyl-alpha-phenylnitrone、3376-24-7、N-tert-butyl-1-phenylmethanimine oxide、Phenyl-N-tert-butylnitrone、N-tert-Butyl-a-phenylnitrone、N-tert-Butyl-、A-phenylnitrone、benzylidene-tert-butylamine oxide、Pbn [MI]、n-tert-butyl phenyl nitrone、(Z)-benzylidene(、N-叔丁基苯硝酮、PBN

产品性质

CAS编号：3376-24-7

分子式：C11H15NO

分子量：177.24

Beilstein号：2044028

EC号：222-168-6

MDL号：MFCD00008799

PubChem编号：638877

别名：N-叔丁基苯硝酮|PBN

英文别名：n-tert-butyl-alpha-phenylnitrone|3376-24-7|N-tert-butyl-1-phenylmethanimine oxide|Phenyl-N-tert-butylnitrone|N-tert-Butyl-a-phenylnitrone|N-tert-Butyl-|A-phenylnitrone|benzylidene-tert-butylamine oxide|Pbn [MI]|n-tert-butyl phenyl nitrone|(Z)-benzylidene(

规格或纯度：95%

英文名称：N-tert-Butyl-α-phenylnitrone

生化机理：细胞可渗透\无Xa0胚根\ xa0陷阱。抑制LPS诱导的NF-κBDNA结合活性，抑制COX-2催化活性并抑制大鼠肝微粒体中的脂质过氧化。阻止活性氧指示iNOS。

应用：一种Cox-2抑制剂。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).一种Cox-2抑制剂。N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).A Cox-2 inhibitor.

IUPAC Name：N-tert-butyl-1-phenylmethanimine oxide

INCHI：InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-

InChi Key：IYSYLWYGCWTJSG-XFXZXTDPSA-N

Canonical SMILES：CC(C)(C)[N+](=CC1=CC=CC=C1)[O-]

Isomeric SMILES：CC(C)(C)/[N+](=C/C1=CC=CC=C1)/[O-]

WGK Germany：3

RTECS：TX1760000

PubChem CID：638877

Reaxy-Rn：1841513

溶解性：溶于DMSO (10 mg/ml), 氯仿 (50 mg/ml), 和水(20 mg/ml).

密度：0.99

敏感性：对空气敏感

熔点：72-75°C

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装