产品名称

英文名称：NU7026

同义词

154447-35-5、NU7026、NU 7026、DNA-PK Inhibitor II、2-(Morpholin-4-yl)-benzo[h]chromen-4-one、NU-7026、2-morpholino-4H-benzo[h]chromen-4-one、LY-293646、LY293646、2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one、2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one、DJ7RQT6

产品性质

CAS编号：154447-35-5

分子式：C17H15NO3

分子量：281.31

MDL号：MFCD06798345

PubChem编号：9860529

英文别名：154447-35-5|NU7026|NU 7026|DNA-PK Inhibitor II|2-(Morpholin-4-yl)-benzo[h]chromen-4-one|NU-7026|2-morpholino-4H-benzo[h]chromen-4-one|LY-293646|LY293646|2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one|2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one|DJ7RQT6

规格或纯度：≥98%

英文名称：NU7026

生化机理：DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC 50 = 0.23 μM). Increases G 2 /M arrest and inhibits double-strand break repair.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：NU7026是一种有效的DNA-PK抑制剂，IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，抑制ATM和ATR活性。An antiproliferative agent, and inhibitor of DNA-PK.NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.An antiproliferative agent, and inhibitor of DNA-PK.

IUPAC Name：2-morpholin-4-ylbenzo[h]chromen-4-one

INCHI：InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChi Key：KKTZALUTXUZPSN-UHFFFAOYSA-N

Canonical SMILES：C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

Isomeric SMILES：C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

WGK Germany：3

PubChem CID：9860529

ChEMBL Ligand：CHEMBL104468

CAS Registry No.：154447-35-5

溶解性：Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装