产品名称

英文名称：Milrinone

同义词

milrinone、78415-72-2、Primacor、Milrinonum、Milrila、Milrinona、Milrinonum [Latin]、Win-47203-2、1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile、WIN 47203、YM 018、2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile、CCRIS 3795、6-methyl-2-oxo-5-(、米利酮、米力农

产品性质

CAS编号：78415-72-2

分子式：C12H9N3O

分子量：211.22

EC号：278-903-6

MDL号：MFCD00133539

PubChem编号：4197

别名：米利酮|米力农

英文别名：milrinone|78415-72-2|Primacor|Milrinonum|Milrila|Milrinona|Milrinonum [Latin]|Win-47203-2|1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile|WIN 47203|YM 018|2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile|CCRIS 3795|6-methyl-2-oxo-5-(

规格或纯度：≥99%

英文名称：Milrinone

生化机理：DescriptionIC50 Value 2mM( inhibiting human platelet aggregation) [3]Milrinone is a phosphodiesterase III inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.in vitro Milrinone inhibited PDE4 in addition to PDE3 activity. In isolated rabbit cardiomyocytes, milrinone (>10 microM) caused greater elevations in intracellular cAMP and calcium than cilostazol [1]. cilostazol and milrinone were equally effective in inhibiting human platelet aggregation with a median inhibitory concentration (IC50) of 0.9 and 2 microM, respectively. In rabbit ventricular myocytes, however, cilostazol elevated cAMP levels to a significantly lesser extent (p < 0.05 vs. milrinone) [3].in vivo Increased blood concentrations of milrinone were associated with increased inhibition of ADP and AA-induced platelet activation (P < 0.0001). Milrinone at a blood concentration of 300 ng/mL mark.Potent, cell-permeable, selective phosphodiesterase 3 inhibitor (IC 50 = 0.42 μM). Inhibits cAMP. Cardiotonic and vasodilator agent. Orally active. Active in vivo and in vitro .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：MilrinoneProduct ApplicationIt is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

PubChem SID：488179820

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179820

IUPAC Name：6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile

INCHI：InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChi Key：PZRHRDRVRGEVNW-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

Isomeric SMILES：CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

WGK Germany：3

RTECS：DW1762000

PubChem CID：4197

Reaxy-Rn：3546821

CAS Registry No.：78415-72-2

DrugBank Ligand：DB00235

Wikipedia：Milrinone

ChEBI：CHEBI50693

ChEMBL Ligand：CHEMBL189

RCSB PDB Ligand：MIL

PEP：milrinone

DrugCentral Ligand：1809

溶解性：DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P330,P361+P364,P301+P316,P316

Merck Index：6197

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装