产品名称

英文名称：Azasetron HCl

同义词

azasetron hydrochloride、123040-16-4、Azasetron HCl、123040-69-7、Serotone、Y-25130 hydrochloride、141922-90-9、Azasetron (hydrochloride)、AZASETRONHYDROCHLORIDE、Azasetron hydrochloride [JAN]、123040-93-7、123040-96-0、477243-03-1、D-erythro-Sphingosine (Brain, Porci、盐酸阿扎司琼

产品性质

CAS编号：123040-16-4

分子式：C17H20ClN3O3·HCl

分子量：386.27

PubChem编号：115000

别名：盐酸阿扎司琼

英文别名：azasetron hydrochloride|123040-16-4|Azasetron HCl|123040-69-7|Serotone|Y-25130 hydrochloride|141922-90-9|Azasetron (hydrochloride)|AZASETRONHYDROCHLORIDE|Azasetron hydrochloride [JAN]|123040-93-7|123040-96-0|477243-03-1|D-erythro-Sphingosine (Brain, Porci

规格或纯度：≥99%

英文名称：Azasetron HCl

生化机理：Y-25130 Hydrochloride is a potent and selective SR-3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the SR-3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice.Potent, selective, competitive 5-HT3 receptor antagonist (K i = 0.33 nM) used in the management of nausea and vomiting induced by cancer chemotherapy.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Azasetron HCl是一种选择性5-HT3受体拮抗剂，IC50为0.33 nM，用于癌症化疗引起的恶心和呕吐。A potent and selective SR-3 antagonistAzasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.A potent and selective SR-3 antagonist

IUPAC Name：N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;hydrochloride

INCHI：InChI=1S/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H

InChi Key：DBMKBKPJYAHLQP-UHFFFAOYSA-N

Canonical SMILES：CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl

Isomeric SMILES：CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl

PubChem CID：115000

溶解性：Soluble in water (25 mg/ml), and DMSO (10 mM).

敏感性：易吸潮

熔点：301-303°C

象形图：

信号词：Warning

危险声明：H361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

产品包装