产品名称

英文名称：Picropodophyllotoxin

同义词

Picropodophyllotoxin;Picropodophyllin;PPP、KBioGR_002538、0F35AOI227、1352873-82-5、DTXSID9025740、Kyselina isoftalova、CS-1184、AC-36894、CCG-39920、KBio2_007252、PODOPHYLLOTOXIN IMPURITY A [EP IMPURITY]、2-[2-hydroxyethyl(propan-2-yl)amino]ethanol、Benzoyl chloride、IGF-1R 抑制剂

产品性质

CAS编号：477-47-4

分子式：C22H22O8

分子量：414.41

MDL号：MFCD01742647

PubChem编号：72435

别名：IGF-1R 抑制剂

英文别名：Picropodophyllotoxin;Picropodophyllin;PPP|KBioGR_002538|0F35AOI227|1352873-82-5|DTXSID9025740|Kyselina isoftalova|CS-1184|AC-36894|CCG-39920|KBio2_007252|PODOPHYLLOTOXIN IMPURITY A [EP IMPURITY]|2-[2-hydroxyethyl(propan-2-yl)amino]ethanol|Benzoyl chloride

规格或纯度：分析标准品,≥98%

英文名称：Picropodophyllotoxin

生化机理：Picropodophyllotoxin (PPP) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Picropodophyllotoxin exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Picropodophyllotoxin inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.Selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Reduces pAkt and pErk1/2. Does not compete with ATP and may inhibit IGF-1R autophosphorylation. Anticancer agent. Active in vitro and in vivo .

应用：苦鬼臼毒素是胰岛素样生长因子-I（IGF-I）受体激酶抑制剂。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：苦鬼臼毒素是胰岛素样生长因子-I（IGF-I）受体激酶抑制剂。Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

IUPAC Name：(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

INCHI：InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1

InChi Key：YJGVMLPVUAXIQN-HAEOHBJNSA-N

Canonical SMILES：COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O

Isomeric SMILES：COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O

WGK Germany：3

RTECS：LV2510000

PubChem CID：72435

UN Number：3462

CAS Registry No.：477-47-4

ChEMBL Ligand：CHEMBL283120

DrugBank Ligand：DB01179

密度：1.37

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH312 Harmful in contact with skin

预防措施声明：P261,P305+P351+P338,P280,P301+P310

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装