产品名称

英文名称：Anagrelide HCl

同义词

ANAGRELIDE HYDROCHLORIDE、58579-51-4、Anagrelide HCL、Agrylin、Thromboreductin、Agrelin、Anagrelide (hydrochloride)、Anagrelid hydrochlorid、6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride、BL 4162A、Anagrelide hydrochloride [USAN]、BL-4162、盐酸阿那格雷

产品性质

CAS编号：58579-51-4

分子式：C10H7Cl2N3O·HCl

分子量：292.55

PubChem编号：135413494

别名：盐酸阿那格雷

英文别名：ANAGRELIDE HYDROCHLORIDE|58579-51-4|Anagrelide HCL|Agrylin|Thromboreductin|Agrelin|Anagrelide (hydrochloride)|Anagrelid hydrochlorid|6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride|BL 4162A|Anagrelide hydrochloride [USAN]|BL-4162

规格或纯度：≥98%

英文名称：Anagrelide HCl

生化机理：Anagrelide hydrochloride is a potent PDE3 (type III phosphodiesterase) inhibitor (IC50 = 36 nM). Produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation and inhibits platelet aggregation.Potent cAMP PDE-3 inhibitor (IC 50 = 36 nM). Reduces megakaryocyte development. Shows selective antimyeloproliferative effects. Shows potent platelet lowering effects in vivo. Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Anagrelide盐酸盐 (BL4162A) 对血小板增多症有效。A potent type III phosphodiesterase inhibitor

PubChem SID：488202861

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488202861

IUPAC Name：6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;hydrochloride

INCHI：InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H

InChi Key：TVWRQCIPWUCNMI-UHFFFAOYSA-N

Canonical SMILES：C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl

Isomeric SMILES：C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl

WGK Germany：3

PubChem CID：135413494

溶解性：Soluble in DMSO (10 mM), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and acetone.

敏感性：对湿度敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

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