产品名称

英文名称：ZM-447439

同义词

331771-20-1、ZM-447439、ZM 447439、ZM447439、N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE、N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide、TCMDC-125873、C29H31N5O4、CHEMBL202721、RSN3P9776R、Ben

产品性质

CAS编号：331771-20-1

分子式：C29H31N5O4

分子量：513.59

PubChem编号：9914412

英文别名：331771-20-1|ZM-447439|ZM 447439|ZM447439|N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE|N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide|TCMDC-125873|C29H31N5O4|CHEMBL202721|RSN3P9776R|Ben

规格或纯度：≥98%

英文名称：ZM-447439

生化机理：ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000 nM, Ki=100nM), ARK-2 (B) (IC50= 50 nM, Ki= 0.36 nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound specifically interacts at the ATP-binding site and at the adjacent cleft, found only in aurora kinases. In the presence of Z-M447439, chromosome alignment, segregation, and cytokinesis during mitosis are unsuccessful. Studies show that ZM-447439 can override the spindle assembly checkpoint and accelerate meiosis I in mouse oocytes.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果按照产品小瓶上的说明进行存放，并且小瓶保持紧密密封，则产品最多可存放6个月。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。

产品介绍：ZM 447439是一种选择性的，ATP竞争性Aurora A和Aurora B抑制剂，IC50分别为110 nM和130 nM，作用于Aurora A/B比作用于MEK1， Src， Lck选择性高8倍，对CDK1/2/4， Plk1， Chk1等几乎没有作用效果。A selective inhibitor of ARK-1, ARK-2, and ARK-3.ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.A selective inhibitor of ARK-1, ARK-2, and ARK-3.

IUPAC Name：N-[4-[[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenyl]benzamide

INCHI：InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)

InChi Key：OGNYUTNQZVRGMN-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

PubChem CID：9914412

CAS Registry No.：331771-20-1

ChEMBL Ligand：CHEMBL202721

Wikipedia：ZM447439

RCSB PDB Ligand：447

溶解性：Soluble in DMSO (25 mg/ml), methanol, water (<1 mg/ml) at 25 °C, ethanol (48 mg/ml) at 25 °C, DMF (~20 mg/ml), and DMSOPBS (11, pH 7.2) (~0.5 mg/ml).

产品包装