产品名称

英文名称：PNU-120596

同义词

501925-31-1、PNU-120596、1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea、PNU 120596、PNU120596、NSC 216666、N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA、1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea、9EZT3P

产品性质

CAS编号：501925-31-1

分子式：C13H14ClN3O4

分子量：311.72

MDL号：MFCD00095313

PubChem编号：311434

英文别名：501925-31-1|PNU-120596|1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea|PNU 120596|PNU120596|NSC 216666|N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA|1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea|9EZT3P

规格或纯度：≥98% (HPLC)

英文名称：PNU-120596

生化机理：PNU 120596 is a type II positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor (AChR) located on the somatodendritic membrane of hippocampal interneurons. This modulator increases the frequency of acetylcholine-evoked GABAergic postsynaptic currents in pyramidal neurons, which can be suppressed by TTX. In addition, studies show that PNU 120596 increases the average time the channel of AChR is open, but does not have any effect on the selectivity of ions flowing throμgh the channel. Furthermore, PNU 120596 has little effect on α4β2, α3β4 and α9α10 receptors. Alternate studies indicate that PNU 120596 increases the effects of choline on native α7-containing AChRs activating these receptors, thus producing single ion channel openings which result in an influx of calcium ions, that can be inhibited with the addition of methyllycaconitine.Competitive, type II positive allosteric modulator for α7nAChR (EC 50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PNU-120596是一种有效的α7 nAChR变构调节剂，EC50为216 nM。A type II positive allosteric modulator.PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.A type II positive allosteric modulator.

PubChem SID：488189427

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488189427

IUPAC Name：1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea

INCHI：InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)

InChi Key：CEIIEALEIHQDBX-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl

Isomeric SMILES：CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl

WGK Germany：3

PubChem CID：311434

CAS Registry No.：501925-31-1

ChEMBL Ligand：CHEMBL257591

Wikipedia：PNU-120,596

RCSB PDB Ligand：I34

溶解性：Soluble in DMSO (62 mg/ml), methanol (1 mg/ml), acetonitrile (0.5 mg/ml), ethanol (1 mg/ml), and water (<1 mg/ml).

产品包装