产品名称

英文名称：Lapatinib

同义词

Lapatinib、231277-92-2、Lapatinib Ditosylate、Tykerb、GW572016、GW 572016、Lapatinib [INN]、Lapatinib base、Tyverb、388082-78-8、Lapatinib (INN)、Lapatinib free base、N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)q、N-[3-氯-4-[(3-氟苄基)氧基]苯基]-6-[5-[[(2-(甲磺酰基)乙基]氨基]甲基]呋喃-2-基]喹唑啉-4-胺、N-[3-氯-4-[(3-氟苄基)氧基]苯基]-6-[5-[[[2-(甲磺酰基)乙基]氨基]甲基]-2-呋喃基]-4-氨基喹唑啉

产品性质

CAS编号：231277-92-2

分子式：C29H26ClFN4O4S

分子量：581.06

EC号：642-915-3,878-720-7

MDL号：MFCD09264194

PubChem编号：208908

别名：N-[3-氯-4-[(3-氟苄基)氧基]苯基]-6-[5-[[(2-(甲磺酰基)乙基]氨基]甲基]呋喃-2-基]喹唑啉-4-胺|N-[3-氯-4-[(3-氟苄基)氧基]苯基]-6-[5-[[[2-(甲磺酰基)乙基]氨基]甲基]-2-呋喃基]-4-氨基喹唑啉

英文别名：Lapatinib|231277-92-2|Lapatinib Ditosylate|Tykerb|GW572016|GW 572016|Lapatinib [INN]|Lapatinib base|Tyverb|388082-78-8|Lapatinib (INN)|Lapatinib free base|N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)q

规格或纯度：≥99%

英文名称：Lapatinib

生化机理：Lapatinib is an antineoplastic agent used in breast cancer research research. It appears to be a tyrosine kinase inhibitor which interrupts the Neu/ ErbB2 and EGFR (epidermal growth factor receptor) pathways, thus inhibiting ErbB-overexpressing tumors. Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation in solid tumor cells. Lapatinib is an inhibitor of EGFR and Neu/ ErbB2.Cell-permeable, potent dual tyrosine kinase inhibitor of EGFR and HER2 (ERBB2)\xa0(IC 50 values are\xa03 nM\xa0and 13 nM respectively).\xa0Also inhibits HER4 (IC 50 = 347 nM).\xa0Reduces tyrosine phosphorylation of EGFR and HER2

应用：An antineoplastic agent used in breast cancer research

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Lapatinib可形成Lapatinib的二甲苯磺酸盐，是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2和9.8 nM。An antineoplastic agent used in breast cancer researchLapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.An antineoplastic agent used in breast cancer research

IUPAC Name：N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

INCHI：InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChi Key：BCFGMOOMADDAQU-UHFFFAOYSA-N

Canonical SMILES：CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Isomeric SMILES：CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

关联CAS：231277-92-2,913989-15-8,388082-78-8

PubChem CID：208908

NSC Number：745750

MeSH Entry Terms：GW 282974X;GW 572016;GW-282974X;GW-572016;GW282974X;GW572016;lapatinib;lapatinib ditosylate;N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine;Tykerb

CAS Registry No.：231277-92-2

DrugBank Ligand：DB01259

Wikipedia：Lapatinib

DiscoveRx TREEspot：Lapatinib|

ChEMBL Ligand：CHEMBL554

RCSB PDB Ligand：FMM

PEP：lapatinib

Reactome Reaction：R-HSA-9652264, R-HSA-9665412, R-HSA-9665121, R-HSA-9665702, R-HSA-1220610, R-HSA-9665284

Reactome Drug：R-ALL-1216521

DrugCentral Ligand：1548

溶解性：DMSO 100 mg/mL (172.09 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)

敏感性：对空气敏感，对热敏感

熔点：147 °C

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P263,P203,P318,P319

产品包装