产品名称

英文名称：Gaboxadol Hydrochloride

同义词

GABOXADOL HYDROCHLORIDE、THIP hydrochloride、85118-33-8、Gaboxadol (hydrochloride)、Gaboxadol HCl、478RVH3TVD、85118-33-8 (HCl)、4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride、4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3(2H)-one monohydrochloride、4,、加波沙朵 盐酸盐、4,5,6,7-四氢异噁唑[5,4-c]吡啶-3-醇 盐酸盐、THIP 盐酸盐、GAB氧杂DOL盐酸盐、4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇盐酸盐

产品性质

CAS编号：85118-33-8

分子式：C6H8N2O2 · HCl

分子量：176.6

EC号：285-687-7

MDL号：MFCD00055180

PubChem编号：5702253

别名：加波沙朵 盐酸盐|4,5,6,7-四氢异噁唑[5,4-c]吡啶-3-醇 盐酸盐|THIP 盐酸盐|GAB氧杂DOL盐酸盐|4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇盐酸盐

英文别名：GABOXADOL HYDROCHLORIDE|THIP hydrochloride|85118-33-8|Gaboxadol (hydrochloride)|Gaboxadol HCl|478RVH3TVD|85118-33-8 (HCl)|4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride|4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3(2H)-one monohydrochloride|4,

规格或纯度：≥98%(HPLC)

英文名称：Gaboxadol Hydrochloride

生化机理：具有系统活性的GABAA受体激动剂和GABAA-ρ受体拮抗剂。显示抗伤害性，抗惊厥和镇静作用。催眠药，可增强大鼠非快速眼动睡眠中的δ活性。

储存温度：2-8°C储存,避光,充氩

运输条件：冰袋运输

产品介绍：产品介绍Gaboxadol hydrochloride (Lu 02-030 hydrochloride) 是一种强效有力的 GABAA receptor 的激动剂和 GABAC receptors 受体拮抗剂 (IC50=25 μM)。Gaboxadol hydrochloride 在亚基 α1β2γ2 显示部分激动剂功效，ED50 值为 143 µM，在 α5 亚基显示出一个完整的受体激动剂功效 (ED50=28-129 µM) 以及在 α4β3δ 亚基也有激动作用 (ED50= 6 µM)。Gaboxadol hydrochloride 是一种非阿片类试剂。Product descriptionGaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid agent.ApplicationGaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

IUPAC Name：4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one;hydrochloride

INCHI：InChI=1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H

InChi Key：ZDZDSZQYRBZPNN-UHFFFAOYSA-N

Canonical SMILES：C1CNCC2=C1C(=O)NO2.Cl

Isomeric SMILES：C1CNCC2=C1C(=O)NO2.Cl

PubChem CID：5702253

溶解性：溶于water, 最高浓度 (mg/mL) 17.66, 最高浓度(mM) 100；溶于DMSO, 最高浓度 (mg/mL) 17.66, 最高浓度(mM) 100

敏感性：对光线、湿度敏感

熔点：236 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH336 May cause drowsiness or dizziness

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：4321

产品包装