产品名称

英文名称：LY-294,002 hydrochloride

同义词

LY-294,002 hydrochloride、934389-88-5、LY 294002 HYDROCHLORIDE、LY-294002 hydrochloride、LY294002 (hydrochloride)、LY294002 Hydrochloride、2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride、2-morpholin-4-yl-8-phenylchromen-4-one;hydrochloride、2-(mor、2-(4-吗啉基)-8-苯基-1(4H)-苯并吡喃-4-酮 盐酸盐

产品性质

CAS编号：934389-88-5

分子式：C19H18ClNO3

分子量：343.8

PubChem编号：11957589

别名：2-(4-吗啉基)-8-苯基-1(4H)-苯并吡喃-4-酮 盐酸盐

英文别名：LY-294,002 hydrochloride|934389-88-5|LY 294002 HYDROCHLORIDE|LY-294002 hydrochloride|LY294002 (hydrochloride)|LY294002 Hydrochloride|2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride|2-morpholin-4-yl-8-phenylchromen-4-one;hydrochloride|2-(mor

规格或纯度：98% (HPLC)

英文名称：LY-294,002 hydrochloride

生化机理：典型的PI 3-激酶抑制剂（PI3-Kβ，PI3-Kα，PI3-Kδ和PI3-Kγ的IC50值分别为0.31、0.73、1.06和6.60μM）。还抑制其他激酶，包括CK2，mTOR，PLK1，PIM1和PIM3。在体外和体内抑制人结肠癌细胞的增殖并诱导其凋亡。抑制mESC的增殖。抑制大鼠肝细胞的自噬螯合。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Product DescribtionLY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.Product ApplicationLY-294,002 hydrochloride has been used in the inhibition ofphosphoinositide 3-kinase (PI3K) in human lung cancer cell lineautophagy in mesenchymal stem cells (MSCs).serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

PubChem SID：488197808

IUPAC Name：2-morpholin-4-yl-8-phenylchromen-4-one;hydrochloride

INCHI：InChI=1S/C19H17NO3.ClH/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14;/h1-8,13H,9-12H2;1H

InChi Key：OQZQSRICUOWBLW-UHFFFAOYSA-N

Canonical SMILES：C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl

Isomeric SMILES：C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl

WGK Germany：3

PubChem CID：11957589

溶解性：溶于DMSO, 最高浓度 (mg/mL) None, 最高浓度(mM) 25；溶于ethanol, 最高浓度 (mg/mL) None, 最高浓度(mM) 5

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装