产品名称

英文名称：2-PMPA

同义词

2-(phosphonomethyl)pentanedioic acid、173039-10-6、2-PMPA、PMPA(NAALADaseinhibitor)、PMPA (NAALADase inhibitor)、PMPA free acid、2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID、XH88WJG9LJ、Pentanedioic acid, 2-(phosphonomethyl)-、CHEMBL47009、173039-10-6 (free acid)、UNII-XH、2-膦酰基甲基戊二酸、2-(膦酰基甲基)-戊二酸

产品性质

CAS编号：173039-10-6

分子式：C6H11O7P

分子量：226.12

MDL号：MFCD00940167

PubChem编号：10130754

别名：2-膦酰基甲基戊二酸|2-(膦酰基甲基)-戊二酸

英文别名：2-(phosphonomethyl)pentanedioic acid|173039-10-6|2-PMPA|PMPA(NAALADaseinhibitor)|PMPA (NAALADase inhibitor)|PMPA free acid|2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID|XH88WJG9LJ|Pentanedioic acid, 2-(phosphonomethyl)-|CHEMBL47009|173039-10-6 (free acid)|UNII-XH

规格或纯度：98% (HPLC)

英文名称：2-PMPA

生化机理：2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静脉内可卡因自我给药。此外，它还抑制可卡因诱导的寻求毒品行为的恢复。2-PMPA 可降低麻醉小鼠脑内血氧水平依赖（BOLD）信号。2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII). 2-(phosphonomethyl)pentanedioic acid (2-PMPA) blocks intravenous cocaine self-administration maintained by low unit doses of cocaine. In addition, it also inhibits cocaine-induced reinstatement of drug-seeking behavior. 2-PMPA reduces blood oxygen-level dependent (BOLD) signals in brain of anesthetized mice. 2-PMPA is a potent (IC50 ~ 1 nM) and selective inhibitor of Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA). 2-PMPA has neuroprotective activity activity. 2-PMPA has been shown to prevent and treat cognitive impairment in the EAE model of multiple sclerosis and to protect against soman-induced neuropathology.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍2-PMPA是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。

IUPAC Name：2-(phosphonomethyl)pentanedioic acid

INCHI：InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)

InChi Key：ISEYJGQFXSTPMQ-UHFFFAOYSA-N

Canonical SMILES：C(CC(=O)O)C(CP(=O)(O)O)C(=O)O

Isomeric SMILES：C(CC(=O)O)C(CP(=O)(O)O)C(=O)O

RTECS：SA0454800

PubChem CID：10130754

溶解性：Soluble to 100 mM in sterile water

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P302+P352,P264,P337+P313,P362+P364,P332+P313

产品包装