产品名称

英文名称：Arg-Gly-Asp-Ser

同义词

Arg-gly-asp-ser、91037-65-9、Rgds peptide、Fibronectin tetrapeptide、Arginyl-glycyl-aspartyl-serine、AC6UDA2MFC、CHEMBL265628、(3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutano、RGDS、L-精氨酰甘氨酰-L-alpha-天冬氨酰-L-丝氨酸

产品性质

CAS编号：91037-65-9

分子式：C15H27N7O8

分子量：433.42

MDL号：MFCD00076452

PubChem编号：107775

别名：RGDS|L-精氨酰甘氨酰-L-alpha-天冬氨酰-L-丝氨酸

英文别名：Arg-gly-asp-ser|91037-65-9|Rgds peptide|Fibronectin tetrapeptide|Arginyl-glycyl-aspartyl-serine|AC6UDA2MFC|CHEMBL265628|(3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutano

规格或纯度：≥95%(HPLC)

英文名称：Arg-Gly-Asp-Ser

生化机理：在纤连蛋白，纤维蛋白原α和von Willebrand因子上发现保守的四肽序列Arg-Gly-Asp-Ser（RGDS）。与细胞表面的整合素结合。抑制\ xa0凝血酶诱导的血小板与纤连蛋白，纤维蛋白原αa的结合

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：Arg-Gly-Asp-Ser.It is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.It has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages.A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.Arg-Gly-Asp-Ser.It is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.It has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages.A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.

IUPAC Name：(3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid

INCHI：InChI=1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1

InChi Key：NNRFRJQMBSBXGO-CIUDSAMLSA-N

Canonical SMILES：C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O)N)CN=C(N)N

Isomeric SMILES：C(C[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O)N)CN=C(N)N

WGK Germany：3

PubChem CID：107775

溶解性：Soluble in water (1 mg/ml), yielding a clear, colorless solution.

密度：1.65

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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