产品名称

英文名称：Avanafil

同义词

Avanafil、330784-47-9、STENDRA、Spedra、TA 1790、TA-1790、CHEBI66876、(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide、UNII-DR5S136IVO、DR5S136IVO、(S)-4-(3-Chloro-4-methoxybenzylamino)-、阿伐那非、(S)-4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)吡咯烷-1-基]-N-(嘧啶-2-基甲基)嘧啶-5-甲酰胺、阿伐那菲

产品性质

CAS编号：330784-47-9

分子式：C23H26ClN7O3

分子量：483.95

PubChem编号：9869929

别名：阿伐那非|(S)-4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)吡咯烷-1-基]-N-(嘧啶-2-基甲基)嘧啶-5-甲酰胺|阿伐那菲

英文别名：Avanafil|330784-47-9|STENDRA|Spedra|TA 1790|TA-1790|CHEBI66876|(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide|UNII-DR5S136IVO|DR5S136IVO|(S)-4-(3-Chloro-4-methoxybenzylamino)-

规格或纯度：≥99%

英文名称：Avanafil

生化机理：Avanafil is an orally active, potent and selective phosphodiesterase-5 (PDE5) inhibitor (IC50 = 5.2 nM) with superior PDE5 selectivity (19,000-, >10,000-, 121-fold over PDE1, PDE11, PDE6, respectively) when compared with tadalafil (25-fold over PDE11), sildenafil and vardenafil (375-fold over PDE1 & 16 to 21-fold over PDE6).

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

ALogP：2.6

PubChem SID：488196380

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488196380

IUPAC Name：4-[(3-chloro-4-methoxyphenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

INCHI：InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

InChi Key：WEAJZXNPAWBCOA-INIZCTEOSA-N

Canonical SMILES：COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)Cl

Isomeric SMILES：COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCC[C@H]4CO)Cl

PubChem CID：9869929

Wikipedia：Avanafil

ChEBI：CHEBI66876

ChEMBL Ligand：CHEMBL1963681

DrugBank Ligand：DB06237

CAS Registry No.：330784-47-9

PEP：avanafil

RCSB PDB Ligand：E6L

DrugCentral Ligand：4305

溶解性：DMSO 97 mg/mL (200 mM) Water <1 mg/mL (<1 mM) Ethanol <1 mg/mL (<1 mM) , DMSO 97 mg/mL (200 mM) Water <1 mg/mL (<1 mM) Ethanol <1 mg/mL (<1 mM)

敏感性：对空气敏感;对热敏感

比旋光度：-62.0 to -72.0 deg (C=1, methanol)

熔点：165℃

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装