产品名称

英文名称：Tirofiban

同义词

COKMIXFXJJXBQG-NRFANRHFSA-N、(S)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid、TIROFIBAN [VANDF]、DTXCID7085221、DTXSID20162730、(2S)-2-(butylsulfonylamino)-3-(4-(4-piperidin-4-ylbutoxy)phenyl)propanoic acid、D08607、L-Tyrosine, N-(b、替罗非班

产品性质

CAS编号：144494-65-5

分子式：C22H36N2O5S

分子量：440.6

Beilstein号：6182267

MDL号：MFCD05237246

PubChem编号：60947

别名：替罗非班

英文别名：COKMIXFXJJXBQG-NRFANRHFSA-N|(S)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid|TIROFIBAN [VANDF]|DTXCID7085221|DTXSID20162730|(2S)-2-(butylsulfonylamino)-3-(4-(4-piperidin-4-ylbutoxy)phenyl)propanoic acid|D08607|L-Tyrosine, N-(b

规格或纯度：≥98%

英文名称：Tirofiban

生化机理：Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Tirofiban是非肽类，糖蛋白IIb/IIIa拮抗剂。Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.

IUPAC Name：(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid

INCHI：InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1

InChi Key：COKMIXFXJJXBQG-NRFANRHFSA-N

Canonical SMILES：CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O

Isomeric SMILES：CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O

WGK Germany：3

RTECS：YP2364100

PubChem CID：60947

CAS Registry No.：144494-65-5

DrugBank Ligand：DB00775

ChEMBL Ligand：CHEMBL916

Wikipedia：Tirofiban

RCSB PDB Ligand：AGG

PEP：tirofiban

DrugCentral Ligand：2680

溶解性：DMSO 0.005 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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