产品名称

英文名称：MPEP

同义词

MPEP、2-Methyl-6-(phenylethynyl)pyridine、96206-92-7、6-Methyl-2-(phenylethynyl)pyridine、2-methyl-6-(2-phenylethynyl)pyridine、7VC0YVI27Y、CHEMBL66654、CHEBI64159、Pyridine, 2-methyl-6-(phenylethynyl)-、2-methyl-6-(phenylethynyl)-pyridine、Tocris-1212、Lopac-M-543、2-甲基-6-(苯基乙炔基)吡啶

产品性质

CAS编号：96206-92-7

分子式：C14H11N

分子量：193.24

PubChem编号：3025961

别名：2-甲基-6-(苯基乙炔基)吡啶

英文别名：MPEP|2-Methyl-6-(phenylethynyl)pyridine|96206-92-7|6-Methyl-2-(phenylethynyl)pyridine|2-methyl-6-(2-phenylethynyl)pyridine|7VC0YVI27Y|CHEMBL66654|CHEBI64159|Pyridine, 2-methyl-6-(phenylethynyl)-|2-methyl-6-(phenylethynyl)-pyridine|Tocris-1212|Lopac-M-543

规格或纯度：≥98%

英文名称：MPEP

生化机理：MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.Subtype selective and potent non-competitive mGlu 5 antagonist (IC 50 = 36 nM). Central effects following systemic administration in vivo .

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：MPEP是mGlu5受体非竞争性拮抗剂，IC50为36 nM，还是mGlu4受体的正向变构调节剂。MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

PubChem SID：488194193

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488194193

IUPAC Name：2-methyl-6-(2-phenylethynyl)pyridine

INCHI：InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3

InChi Key：NEWKHUASLBMWRE-UHFFFAOYSA-N

Canonical SMILES：CC1=NC(=CC=C1)C#CC2=CC=CC=C2

Isomeric SMILES：CC1=NC(=CC=C1)C#CC2=CC=CC=C2

PubChem CID：3025961

Wikipedia：2-Methyl-6-(phenylethynyl)pyridine

ChEMBL Ligand：CHEMBL66654

BindingDB Ligand：50084137

CAS Registry No.：96206-92-7

GPCRdb Ligand：MPEP

溶解性：DMSO 39 mg/mL Water <1 mg/mL Ethanol 39 mg/mL

敏感性：对空气敏感；对热敏感

熔点：47 °C

产品包装