产品名称

英文名称：Sorafenib Tosylate

同义词

Sorafenib tosylate、475207-59-1、Nexavar、Nexavar(R)、Sorafenib tosylate [USAN]、Sorafenib (Tosylate)、BAY 54-9085、Sorafenib tosilate、UNII-5T62Q3B36J、DTXSID9047839、BAY43-9006 mono-p-tosylate、CHEBI50928、5T62Q3B36J、BAY 43-9006 mono-p-tosylate、475207-59-1 (tosyla、甲苯磺酸索拉非尼

产品性质

CAS编号：475207-59-1

分子式：C21H16ClF3N4O3·C7H8O3S

分子量：637.03

PubChem编号：406563

别名：甲苯磺酸索拉非尼

英文别名：Sorafenib tosylate|475207-59-1|Nexavar|Nexavar(R)|Sorafenib tosylate [USAN]|Sorafenib (Tosylate)|BAY 54-9085|Sorafenib tosilate|UNII-5T62Q3B36J|DTXSID9047839|BAY43-9006 mono-p-tosylate|CHEBI50928|5T62Q3B36J|BAY 43-9006 mono-p-tosylate|475207-59-1 (tosyla

规格或纯度：≥99%

英文名称：Sorafenib Tosylate

生化机理：Sorafenib Tosylate is an inhibitor of c-Kit, Flk-1, Flt-3/Flk-2, Flt-4, PDGFR-β, Raf-1 and Raf-B

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Sorafenib Tosylate是酪氨酸激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂，同时作用于Raf-1，wtBRAF和V599EBRAF，IC50分别为6 nM， 22 nM和38 nM。An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.

IUPAC Name：4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

INCHI：InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

InChi Key：IVDHYUQIDRJSTI-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Isomeric SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

PubChem CID：406563

溶解性：Soluble in water (<1 mg/ml) at 25 °C, DMSO (127 mg/ml ) at 25 °C, and ethanol (<1 mg/ml ) at 25 °C.

熔点：240-243°C

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH332 Harmful if inhaledH360 May damage fertility or the unborn child

预防措施声明：P261,P273,P280,P405,P501,P264,P260,P271,P270,P304+P340,P330,P203,P301+P317,P318,P317,P319

产品包装