产品名称

英文名称：Tenovin-1

同义词

Tenovin-1、380315-80-0、Tenovin 1、N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide、N-((4-acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide、BIQ6AID2B7、DTXSID1046920、NCGC00181351-01、N-[4-({[(4-tert-butylphenyl)formamido]methanethioyl}amino)phen

产品性质

CAS编号：380315-80-0

分子式：C20H23N3O2S

分子量：369.48

PubChem编号：1013376

英文别名：Tenovin-1|380315-80-0|Tenovin 1|N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide|N-((4-acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide|BIQ6AID2B7|DTXSID1046920|NCGC00181351-01|N-[4-({[(4-tert-butylphenyl)formamido]methanethioyl}amino)phen

规格或纯度：≥98%

英文名称：Tenovin-1

生化机理：Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6. Tenovin-1 is an activator of p21 and p53.p53 Activator. Protects p53 from MDM2 mediated degradation through SirT1 inhibition. Inhibits downstream histone acetylation, activates p21CIP/WAF1. Potent antiproliferative effects in vitro .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Tenovin-1防止MDM2介导的p53的降解，涉及泛素化途径，通过抑制SirT1和SirT2的蛋白脱乙酰活性。An inhibitor of SIRT1 and SIRT2.Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.An inhibitor of SIRT1 and SIRT2.

IUPAC Name：N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

INCHI：InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)

InChi Key：WOWJIWFCOPZFGV-UHFFFAOYSA-N

Canonical SMILES：CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

Isomeric SMILES：CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

PubChem CID：1013376

溶解性：Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml).

产品包装