产品名称

英文名称：Brivanib (BMS-540215)

同义词

Brivanib、649735-46-6、BMS-540215、BMS 540215、Brivanib [USAN]、Brivanib (BMS-540215)、BMS540215、(R)-1-((4-((4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY)-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL)OXY)PROPAN-2-OL、CHEMBL377300、DDU33B674I、(2R)-1-[4-[(4-FLUORO-2-METHYL-1H-、酪氨酸激酶抑制剂、布立尼布

产品性质

CAS编号：649735-46-6

分子式：C19H19FN4O3

分子量：370.39

PubChem编号：11234052

别名：酪氨酸激酶抑制剂|布立尼布

英文别名：Brivanib|649735-46-6|BMS-540215|BMS 540215|Brivanib [USAN]|Brivanib (BMS-540215)|BMS540215|(R)-1-((4-((4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY)-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL)OXY)PROPAN-2-OL|CHEMBL377300|DDU33B674I|(2R)-1-[4-[(4-FLUORO-2-METHYL-1H-

规格或纯度：≥98%

英文名称：Brivanib (BMS-540215)

生化机理：Brivanib is an ATP-competitive inhibitor against human VEGFR-2 and mouse Flk-1 with IC50 of 25 nM and 89 nM, respectively. Brivanib also inhibits VEGFR-1 and FGFR-1 with IC50 of 0.38 and 0.148 μM. Brivanib displays antitumor activities in H3396 xenograft. This compound completely inhibits the tumor growth, with TGI of 85% and 97%, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Brivanib (BMS-540215)是一种ATP竞争性的VEGFR2抑制剂，IC50为25 nM，对VEGFR-1和FGFR-1抑制作用适中，但比作用于PDGFR-β效果强240多倍。An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1

ALogP：3

IUPAC Name：(2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol

INCHI：InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1

InChi Key：WCWUXEGQKLTGDX-LLVKDONJSA-N

Canonical SMILES：CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)O)C

Isomeric SMILES：CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C

PubChem CID：11234052

CAS Registry No.：649735-46-6

Wikipedia：Brivanib

DiscoveRx TREEspot：BMS-540215|

ChEMBL Ligand：CHEMBL377300

Reactome Reaction：R-HSA-2023462

Reactome Drug：R-ALL-2023385

溶解性：Soluble in DMSO (74 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (3 mg/ml at 25 °C).

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

产品包装